Police currently searching for missing midwife Samantha Eastwood have found a body.
A 32-year-old man who had previously been arrested by Staffordshire Police in connection with her disappearance has been re-arrested on suspicion of murder.
The force said two other men, aged 28 and 60, have been arrested on suspicion of assisting an offender.
The 28-year-old went missing on July 27 and was last seen in her uniform leaving work just before 8am.
Forensic teams remain at the scene near Caverswall, Staffordshire and are expected to stay there for some time.
Police said the body has yet to be formally identified and a post-mortem will take place in due course.
Nigel Potts, who owns neighbouring Newhill Farm said he had witnessed a large police presence at a nearby disused quarry on Saturday morning.
He said: "It seems that's where the main focus of the search is. They've been down here for three days."
Mr Potts added that officers had asked to view footage from his CCTV camera on the night Ms Eastwood went missing but his recordings did not go back that far.
Ms Eastwood was last seen in her uniform leaving work at Royal Stoke Hospital at 7.45am on Friday July 27.
The force said neighbours reported hearing a scream in the vicinity of the midwife's house at around 2pm on the day she went missing.
Detective Superintendent Simon Duffy, from the force's Major and Organised Crime Department, said: "The discovery today is not what anyone wanted, and this is now a homicide investigation.
"A 32-year-old man who was previously released on conditional bail has now been re-arrested for murder, and remains in custody.
"Two other men, aged 28 and 60, have been arrested on suspicion of assisting an offender."
He added: "I would like to thank the public for their support, and anyone with any further information is asked to contact us on 101."
Ms Eastwood's sister, Gemma Eastwood, made a tearful appeal for help in tracing her on Friday, saying: "We miss you very much, we need you home where you belong.
"If she's out there, or anyone knows where she is, please get in touch.
"Get her home."
Liz Rix, Chief Nurse, University Hospitals of North Midlands NHS Trust, said: "It is with deep sadness that we announce that Staffordshire Police have discovered a body, yet to be formally identified, in the search for our friend and colleague Samantha Eastwood.
"Our thoughts are with her family and friends during this time. We would like to thank Staffordshire Police for their dedication and support this week."
