She first hit the headlines as the stroppy daughter of rock star Ozzy Osbourne in the TV reality show set in their family home.
Since then, Kelly Osbourne has made her own way as a singer, presenter, model - and now the next star of the hit West End show Chicago.
The 22-year-old will join the cast at the Cambridge Theatre on 10 September in what will be her first professional theatrical role.
She will play Mama Morton, matron of the jail where man-killers Roxie Hart and Velma Kelly are imprisoned. Osbourne follows a string of star names who have joined the production, including Brooke Shields, Claire Sweeney and Denise Van Outen.
Barry Weissler, the Broadway and London producer of Chicago, said: "We're very excited that Kelly is joining the production. She's internationally recognised, she's unique - it's the perfect match."
Osbourne, who will star in the show for seven weeks, said: "It's been a dream of mine to be in the West End. I can't wait to work with such an amazing cast."
